Beaumont Hospital

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Psychiatry Research

The Department of Psychiatry provide a range of consultation-liaison psychiatry services to Beaumont Hospital.  These services encompass the assessment, diagnosis and treatment of people with psychiatric disorder in the setting of a general medical hospital.  We have a substantial input into the Accident and Emergency Department and a considerable amount of our work-load involves the assessment and management of the patients who present following deliberate self harm.

The Department can be divided into four main areas of sub-specialisation:- General Adult Liaison Psychiatry, Neuropsychiatry, Psychiatry of Old Age, and the in-patient Substance Misuse service based in St. Michaels Ward.

We are active academically.

Contact

Professor David Cotter MRCPsych PhD, Consultant Psychiatrist

 

Professor Kieran Murphy

Research projects

A novel high-risk study of schizophrenia susceptibility using a population-based cohort of people with 22q11 Deletion syndrome

We are recruiting a cohort of children and adults with 22q11 Deletion syndrome and are aiming to characterize the psychiatric and neuropsychological phenotypes in people with the disorder.

Structural and functional neuroimaging in people with 22q11 Deletion syndrome

In this study, we are investigating the structural and functional basis of psychiatric and psychological disorder in 22q11 Deletion syndrome using structural and functional magnetic resonance imaging.

Resource for Psychoses Genomics Ireland (RPGI)

The establishment of a resource containing clinical information and DNA from a large number of people with a psychotic disorder

The neurobiology of psychogenic non-epileptic seizures

We are investigating the structure and function of the brain in people with psychogenic non-epileptic seizures.

Treating refractory epilepsy: Psychiatric and psychosocial morbidity before and after surgical treatment

In this study, we are examining the psychiatric complications of epilepsy before and after surgical treatment for epilepsy.

Publications 2009

The Letter-Number Sequencing Test and its association with potential to work among people with psychotic illness. 
Murtagh A, Hurley AL, Kinsella A, Corvin A, Donohoe G, Gill M, O'Callaghan E, Murphy KC.
Eur Psychiatry. 2009 Aug 31. [Epub ahead of print]
PMID: 19720503 [PubMed - as supplied by publisher]

Post-concussion syndrome. 
Foy K, Murphy KC.
Br J Hosp Med (Lond). 2009 Aug;70(8):440-3.
PMID: 19684532 [PubMed - in process]

Psychosis and autism: magnetic resonance imaging study of brain anatomy. 
Toal F, Bloemen OJ, Deeley Q, Tunstall N, Daly EM, Page L, Brammer MJ, Murphy KC, Murphy DG.
Br J Psychiatry. 2009 May;194(5):418-25.
PMID: 19407271 [PubMed - indexed for MEDLINE]

Brain structural differences associated with the behavioural phenotype in children with Williams syndrome. 
Campbell LE, Daly E, Toal F, Stevens A, Azuma R, Karmiloff-Smith A, Murphy DG, Murphy KC.
Brain Res. 2009 Mar 3;1258:96-107. Epub 2008 Dec 11.
PMID: 19118537 [PubMed - indexed for MEDLINE]

A comparative study of cognition and brain anatomy between two neurodevelopmental disorders: 22q11.2 deletion syndrome and Williams syndrome. 
Campbell LE, Stevens A, Daly E, Toal F, Azuma R, Karmiloff-Smith A, Murphy DG, Murphy KC.
Neuropsychologia. 2009 Mar;47(4):1034-44. Epub 2008 Nov 13.
PMID: 19061904 [PubMed - indexed for MEDLINE]

Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults. 
Hallahan B, Daly EM, McAlonan G, Loth E, Toal F, O'Brien F, Robertson D, Hales S, Murphy C, Murphy KC, Murphy DG.
Psychol Med. 2009 Feb;39(2):337-46. Epub 2008 Sep 8.
PMID: 18775096 [PubMed - indexed for MEDLINE]

Related Articles

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Dr MacHale

Research 

Research links are in development with a number of hospital departments including Oncology, Hepatology and Infectious Diseases.

Recent and upcoming publications include

O'Connor R, Fraser L, Whyte M, MacHale S, Masterton G. A comparison of specific positive future expectancies and global hopelessness as predictors of suicidal ideation in a prospective study of repeat self-harmers. Journal of Affective Disorders 2008; 110: 207-214  

MacHale S. Management of the acutely disturbed patient. Abstracts: St Andrew's Day Symposium. J R Coll Physicians Edinb, 2008; 38: 65-66.

O'Connor R, Fraser L, Whyte M, MacHale S, Masterton G. Self-regulation of unattainable goals in suicide attempters: the relationship between goal disengagement, goal reengagement and suicidal ideation Behaviour Research and Therapy 2009; 47: 164-169

MacHale S, Smyth R. The management of depression in the physically ill. RCPsychs e-learning module http://www.psychiatrycpd.org/. updated April 2009

MacHale S, Brown T. Psychological Treatments in Liaison Psychiatry. In Seminars in Liaison Psychiatry 2nd Ed. Wiley (in press)

Other

Invited External Peer reviewer for Cochrane Collaboration Depression, Anxiety and Neurosis Group (2009)

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Professor David Cotter

NARSAD Independent Investigator Award - International

'Test Endowment' NARSAD 2007 Independent Investigator Award
www.narsad.org
Proteomic investigation of schizophrenia hippocampus and mouse hippocampus following exposure to neuroleptics drugs.

Cotter and Prehn

Molecular Medicine Ireland Clinician Scientist Fellowship

www.molecularmedicine

Neuroproteomic Analysis of Schizophrenia and Disease-Associated Neuronal Signalling Defects

Cotter

Stanley Medical Research Institute Project Grant - International  $100,000
#09R-2106
http://www.stanleyresearch.org/dnn/ResearchGrants/Application/tabid/54/Default.aspx 
Stereological investigation of Inferior Parietal lobe in schizophrenia.

Publications 2009

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder. 
Beasley CL, Honavar M, Everall IP, Cotter D.
Schizophr Res. 2009 Dec;115(2-3):156-62.

Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction. 
Manadas B, English JA, Wynne KJ, Cotter DR, Dunn MJ.
Proteomics. 2009 Sep 21;9(22):5194-5198.
PMID: 19771557

Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.
Babovic D, O'Tuathaigh CM, O'Connor AM, O'Sullivan GJ, Tighe O, Croke DT, Karayiorgou M, Gogos JA, Cotter D, Waddington JL.
Neuroscience. 2008 Jul 10. PMID: 18674597

Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. 
Behan AT, Byrne C, Dunn MJ, Cagney G, Cotter DR.
Mol Psychiatry. 2009 Jun;14(6):601-13. Epub 2008 Feb 12.
PMID: 18268500

2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease. 
English JA, Dicker P, Föcking M, Dunn MJ, Cotter DR.
Proteomics. 2009 Jun;9(12):3368-82.
PMID: 19562803

A proteomic investigation of similarities between conventional and herbal antidepressant treatments.
Pennington K, Föcking M, McManus CA, Pariante CM, Dunn MJ, Cotter DR.
J Psychopharmacol. 2009 Jul;23(5):520-30. [Epub ahead of print]
PMID: 18562437

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